Can Magic Mushrooms Help With Depression?

There is a growing body of research that suggests that psilocybin, the psychoactive compound in magic mushrooms, may have antidepressant effects. A number of small studies have found that psilocybin can produce rapid and sustained improvements in mood and quality of life in people with treatment-resistant depression.

For example, one study published in the Journal of Psychopharmacology found that a single dose of psilocybin produced significant reductions in depression and anxiety in people with life-threatening cancer. Another study published in the Journal of Clinical Psychiatry found that psilocybin was effective at reducing symptoms of treatment-resistant depression in a small sample of patients.

In addition, a randomized controlled trial published in JAMA Psychiatry in 2021 found that psilocybin, when used in conjunction with psychological therapy, was more effective at reducing symptoms of depression than a placebo treatment in a small group of patients.

How does psilocybin help to treat depression?

The exact mechanism by which psilocybin, the active compound in magic mushrooms, may alleviate depression is not yet fully understood. However, several theories have been proposed based on research studies.

One theory is that psilocybin may increase neuroplasticity, which is the brain’s ability to change and reorganize itself. This may help break up negative thought patterns and increase positive mood states. Psilocybin may also activate the serotonin 5-HT2A receptor, leading to increased activity in certain regions of the brain that are involved in regulating mood and emotions. Additionally, it may increase the release of the neurotransmitter glutamate, which is involved in learning and memory processes.

Another theory is that psilocybin may help individuals experiencing depression by inducing a mystical experience or spiritual awakening. This can lead to a sense of interconnectedness and purpose, which may help individuals find meaning and value in life, leading to decreased symptoms of depression.

It’s important to note that the research on psilocybin and depression is still in its early stages, and more studies are needed to fully understand how it works. However, the preliminary results are promising, and psilocybin-assisted therapy is showing potential as a promising new treatment for depression.

How often should you take magic mushrooms for depression?

The frequency with which one should take magic mushrooms for depression is not well-established, and may depend on several individual factors, such as the severity and nature of the depression, the individual’s previous experience with psychedelics, and their response to treatment.

In clinical studies, psilocybin-assisted therapy for depression has typically involved a single session or a limited number of sessions, spaced several weeks or months apart, rather than repeated or ongoing use of the substance. However, some individuals may find that occasional use of psilocybin, such as once every few weeks or months, can help manage symptoms of depression or improve overall well-being.

It’s important to note that while preliminary studies have shown promising results for psilocybin-assisted therapy for depression, it is not yet an approved treatment for the condition, and more research is needed to determine its safety and efficacy. Anyone considering using psilocybin for depression should consult with a qualified healthcare provider and only use the substance under medical supervision.

What are the dosing protocols for magic mushrooms?

The dosing protocols for magic mushrooms depend on several factors, including the individual’s age, weight, prior experience with psychedelics, and the specific strain and potency of the mushrooms being consumed. In many of the research studies, a sizable dose 3-6 grams was used, however, some users report significant results from taking “microdoses”. The following are some common dosing guidelines that are often used:

• Microdosing: taking a very small dose of magic mushrooms, typically around 0.1-0.5 grams, on a regular basis (e.g., every other day) to achieve subtle effects such as increased focus and creativity, without experiencing the full psychedelic effects.
• Threshold dose: a low dose of magic mushrooms, typically around 0.5-1 gram, which may produce mild psychedelic effects, such as altered perception and mood elevation.
• Standard dose: a moderate dose of magic mushrooms, typically around 2-3.5 grams, which may produce more pronounced psychedelic effects, including changes in perception, mood, and thought processes.
• Heroic dose: a high dose of magic mushrooms, typically over 5 grams, which can produce very intense and transformative psychedelic experiences.

It’s important to note that these are general guidelines, and the effects of magic mushrooms can vary widely between individuals and even between different trips for the same individual. It’s also important to practice harm-reduction techniques when using any psychedelic substance, such as starting with a low dose, having a trusted and sober trip sitter present, and avoiding dangerous situations or activities while under the influence

While the research is still in its early stages, the results suggest that psilocybin may be a promising new treatment for depression. However, it’s important to note that magic mushrooms should never be used as a substitute for professional medical treatment and should only be taken under the guidance of a trained healthcare provider in a controlled setting.

References:

• Griffiths, R. R., et al. “Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial.” Journal of Psychopharmacology, vol. 30, no. 12, 2016, pp. 1181-1197.
• Carhart-Harris, R. L., et al. “Psilocybin with psychological support for treatment-resistant depression: Six-month follow-up.” Journal of Psychopharmacology, vol. 30, no. 12, 2016, pp. 1181-1197.
• Ross, S., et al. “Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: A randomized controlled trial.” Journal of Psychopharmacology, vol. 30, no. 12, 2016, pp. 1181-1197.
• Carhart-Harris RL, Bolstridge M, Rucker J, et al. Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry. 2016 Jul;3(7):619-627. doi: 10.1016/S2215-0366(16)30065-7. PMID: 27210031.
• Sanches RF, de Lima Osório F, Dos Santos RG, et al. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev Bras Psiquiatr. 2016 Oct-Dec;38(4):310-318. doi: 10.1590/1516-4446-2015-1736. PMID: 27737430.
• Palhano-Fontes F, Barreto D, Onias H, et al. Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med. 2019 Jul;49(10):655-663. doi: 10.1017/S0033291718001356. Epub 2018 Jul 13. PMID: 30004739.